Trifluoromethanesulfonic Acid 1493-13-6 CF₃SO₃H

Ecovia offers high-quality and stable Trifluoromethanesulfonic Acid (CAS 1493-13-6), also known as Triflic Acid or TfOH. We provide various Triflic Acid Derivatives using national production resources. Our goal is to deliver top-notch products and services. If you want to learn more about our products, please contact us.

Trifluoromethanesulfonic acid, commonly known as triflic acid, TFMS, TFSA, HOTf, or TfOH, is a sulfonic acid with the chemical formula CF₃SO₃H. Recognized as one of the strongest acids, it belongs to a group of acids known as "superacids." It is widely utilized in the production of pharmaceuticals, agricultural chemicals, and polymers. The anhydrous form is especially important in fine chemical synthesis due to its high thermal stability, non-oxidizing nature, and resistance to both oxidation and reduction, making it one of the most valuable compounds within the superacid category. In the pharmaceutical industry, trifluoromethanesulfonic acid is used in the synthesis of various drug classes, including nucleosides, antibiotics, steroids, proteins, and glycosides. However, its anhydride form reacts readily with water and has a toxicity profile that is considered unfavorable.Triflic acid cas no is1493-13-6,triflic acid pKa is -14(at 25℃),density of triflic acid is 1.696 g/mL at 25 °C (lit.)

  Triflic acid uses  

Pharmaceuticals

Drug Synthesis: Trifluoromethanesulfonic acid is used in the synthesis of a wide range of drugs, including nucleosides, antibiotics, steroids, proteins, and glycosides. It serves as an efficient catalyst in various chemical reactions, such as esterification and acylation, to help produce these biologically active compounds.
 Catalysis: It is employed as a catalyst in the production of pharmaceuticals, offering enhanced reaction rates and selectivity.

Agricultural Chemicals

Pesticide Synthesis: TFMS is used in the production of agricultural chemicals, particularly in the synthesis of herbicides and pesticides, due to its effectiveness in chemical transformations.

Polymerization

Polymerization Reactions: Triflic acid is utilized in the polymer industry to initiate or catalyze polymerization reactions. It can be used in the synthesis of various high-performance polymers, including those for electronics and coatings.

Fine Chemical Synthesis

Superacid Catalysis: As a superacid, triflic acid is widely employed in fine chemical synthesis, enabling reactions that would otherwise be difficult to achieve with other acids. It is used to catalyze reactions such as Friedel-Crafts acylation, alkylation, and esterification.

Electronics Industry

Synthesis of Semiconductor Materials: It plays a role in the preparation of semiconductors and other electronic materials, where its ability to act as a strong acid can facilitate the synthesis of high-purity compounds.

Petrochemical Industry

Catalysis in Hydrocarbon Processing: TFMS is used in the petrochemical industry for various catalytic processes, such as cracking and alkylation, which are essential in refining crude oil into useful fuels and chemicals.

Hydrophobicity and Surface Modification

Surface Treatment: Trifluoromethanesulfonic acid can be used in surface treatment applications to impart hydrophobic properties to materials, enhancing their resistance to moisture and chemical attack.

Chemical Synthesis of Triflates

Triflate Formation: It is commonly used to create triflate esters (–SO₃CF₃), which are valuable in organic synthesis. These triflate groups are important for facilitating reactions in medicinal chemistry and materials science.

Triflic acid (also known as TFSA, HOTf or TFMS) is a powerful superacid with the chemical formula CF3SO3H. It is widely recognized for its extremely strong acidity, with a pKa value of approximately -14 at 25°C, making it one of the strongest acids available. Triflic acid is often used in its anhydrous form, known as Triflic Acid Anhydride, which is a key reagent in various chemical reactions due to its high reactivity and stability under certain conditions. Triflic acid derivatives, such as triflate esters (–SO₃CF₃), are also commonly synthesized from triflic acid and play important roles in organic chemistry, particularly in catalysis, electrophilic substitution, and as reactive intermediates in pharmaceuticals and fine chemicals synthesis. TfOH (the shorthand for trifluoromethanesulfonic acid) has become a standard in numerous industrial applications, including drug synthesis, polymerization, and electronic materials production, owing to its strong catalytic properties and resistance to both oxidation and reduction.

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