High Purity Trifluoromethanesulfonic Anhydride (Tf₂O)

Trifluoromethanesulfonic anhydride, also known as Triflic Anhydride (CAS No: 358-23-6),abbreviated Tf2O, is an important chemical compound used in organic synthesis. Its molecular structure consists of a trifluoromethyl group (CF₃) attached to a sulfonic anhydride group (SO₂), making it a highly reactive and electrophilic compound. With a density of approximately 1.677 g/cm³, triflic anhydride is commonly used to introduce the trifluoromethanesulfonyl group into organic molecules, which can enhance their reactivity and stability. With a guaranteed purity of 99% minimum, this highly reactive reagent is indispensable for a wide range of advanced chemical transformations.

This compound, also referred to as triflic acid anhydride, is valuable in pharmaceutical, polymer, and fine chemical industries, where it plays a key role in the synthesis of triflates, which are important intermediates in various chemical reactions.Ecovia, as an advanced sales and service provider, provides high purity and high stability of Trifluoromethanesulfonic Anhydride for you, if you have any questions, you can contact us!

Key Properties and Benefits of Trifluoromethanesulfonic Anhydride

Triflic Anhydride offers several advantageous properties for synthetic chemists:

• High Reactivity: Extremely effective for activating alcohols, carboxylic acids, and other functional groups.

• Powerful Triflation Agent: Widely used to introduce the triflate (OTf) group, creating excellent leaving groups for substitution and elimination reactions.

• Effective Acylation Agent: Can be used for acylation reactions under specific conditions.

• Versatile Coupling Agent: Facilitates the formation of new bonds in complex molecule synthesis.

• High Purity (99% min): Ensures reliable and predictable reactivity in sensitive synthetic routes.

Primary Applications

Due to its powerful activating and triflating capabilities, high-purity Triflic Anhydride is extensively used in:

• Organic Synthesis: Key reagent for triflation of alcohols, phenols, and enolates; activation of carboxylic acids for coupling; and various rearrangement reactions.

• Catalysis: Used in the generation of highly active electrophiles or as a promoter in catalytic cycles.

• Synthesis of Pharmaceuticals and Agrochemicals: Essential for constructing complex molecular structures in the synthesis of active pharmaceutical ingredients and agricultural chemicals.

• Materials Science: Employed in the synthesis of monomers and polymers with specific properties.

Choose our 99% min. purity Trifluoromethanesulfonic Anhydride for your demanding synthetic challenges, ensuring high efficiency and yield in your reactions.

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